From top to bottom:
4, 9, 1, 6, 8, 2, 7, 3, 5.
Where are the choices listed with the question? helpless, naked, piping loud
Answer:
<u><em>Once a species starts dwindling in numbers, there's a smaller pool of available mates and often a corresponding lack of genetic diversity. This is the reason it's much healthier to marry a complete stranger than your first cousin, since, otherwise, you run the risk of "inbreeding" undesirable genetic traits, like susceptibility to fatal diseases.</em></u>
Explanation:
So if there is no topic sentence than it would really not sum up your arguement in the paragraph or the point you are stating
This should be a writer's opinion
That is because it might differ based on who was talking. Some might disagree that it has become run-down, or some might say that it has become such way before "just recently".