Answer:
Bridge, sign, man (politician?), Keystone, water
The creation of the Federalist Party, that favored business, a strong government and a lax interpretation of the Constitution, and the Democratic-Republican Party, that wanted a society based on small farms and a weaker core government; changed the nature of politics in the US as they proposed a dichotomy when voting, since the Constitution had been silent about political parties.
They located in an area that traders could reach in a single season.