Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
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Answer:
The influx of calcium ions.
Explanation:
The influx of calcium ions at a certain point produces phase of the action potential also called depolarization which results in the ion movement changes the membrane potential from negative to positive inside the cell.
In action potential, calcium ions may control gene transcription, cell excitability, and neurotransmitter release. In chemical synapses, the influx of calcium ions leads to vesicles filled with neurotransmitters move to the surface of the cell, and into the synaptic cleft release their contents.
Answer:
Volcanoes can be constructive if they happen in the ocean, as they can form islands and therefore be new places for plants and animals to grow and thrive.
Volcanoes can be destructive if they kill a large amount of animals by forming on land.
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The right option is lateral
corticospinal tract
The lateral corticospinal tract functions
in the control of distal muscles such as those of the limbs and the trunk. About
90% of the fibers that travel in the corticospinal tract are found in the
lateral corticospinal tract which makes it the main component of the corticospinal
tract.
<span>Diabetic Ketoacidosis. Most common in type 1 diabetics. </span>
