2. disrupt, upset.
5. mutter, stutter.
DNA Replication in Interphase.
Use it describing the way someone rode something. "But Tait had none of Tillotson's gentleness, and he rode roughshod over the obstacles in his way." (That sentence is from yourdictionary.com by the way :) )
Eleanor - Changes in Motivation
Celeste - Financial Obstacle
Sienna - Educational Obstacle
Corbin - Other Demands on Time
Mateo - Economic Obstacle
Hope this helps!!