Question

Julia had a sibling who died because of a genetic disease as an infant. Before having children, she and her husband Tobias get genetic testing and counseling. They are unlucky.
For the GAA gene, Julia has one normal allele and one totally non-functional allele. Tobias has one normal allele and one totally non-functional allele.

What is the likelihood that an offspring will have Pompe disease?

1.) 0% of having Pompe disease

2.) 25% of having Pompe disease

3.) 50% of having Pompe disease

4.) 75% of having Pompe disease

5.) 100%

Answer 1

There is a 50% chance.

Answer 2

That would be 2.) or 25% of having it because the gene levels, and what not, also because her sibling had it and if she is not the only child, then it would definately be 25% or less. She has a very slim chance, but not a ZERO chance, so its got to be 25% if its going to be anything.