Answer:
Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of the central nervous system characterized by immune-mediated myelin and axonal damage, and chronic axonal loss attributable to the absence of myelin sheaths. T cell subsets (Th1, Th2, Th17, CD8+, NKT, CD4+CD25+ T regulatory cells) and B cells are involved in this disorder, thus new MS therapies seek damage prevention by resetting multiple components of the immune system. The currently approved therapies are immunoregulatory and reduce the number and rate of lesion formation but are only partially effective. This review summarizes current understanding of the processes at issue: myelination, demyelination and remyelination—with emphasis upon myelin composition/architecture and oligodendrocyte maturation and differentiation. The translational options target oligodendrocyte protection and myelin repair in animal models and assess their relevance in human. Remyelination may be enhanced by signals that promote myelin formation and repair. The crucial question of why remyelination fails is approached is several ways by examining the role in remyelination of available MS medications and avenues being actively pursued to promote remyelination including: (i) cytokine-based immune-intervention (targeting calpain inhibition), (ii) antigen-based immunomodulation (targeting glycolipid-reactive iNKT cells and sphingoid mediated inflammation) and (iii) recombinant monoclonal antibodies-induced remyelination.Keywords: calpain, central nervous system, demyelination, fingolimod, glycolipids, lipids, multiple sclerosis, myelin, myelination, NKT cells, oligodendrocytes, remyelination, T cells
Explanation:
Michael
was subjected to much stress as an infant due to repeated episodes of
family violence. Now, as an adult, he shuts down emotionally whenever he
starts to experience any type of stress. This response may be because
during infancy stress hormones in his brain were:<span> overproduced.</span>
False, researchers have found that these diseases are a "gay-disease" meaning that it is twice as likely to happen to gay or bisexual men than it is for heterosexual
Probably A (?) Because the chef is using more than required, meaning it'll cost more to make.
When you swallow, a flap called the epiglottis moves to block the entrance of food particles into your larynx and lungs. The muscles of the larynx pull upward to assist with this movement. They also tightly close during swallowing. That prevents food from entering your lungs.
