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KengaRu [80]
4 years ago
15

What are two internal factors that organisms respond to?

Biology
2 answers:
Phantasy [73]4 years ago
8 0

Organism respond to many internal factors. For example temperature, and homeostasis.

Amanda [17]4 years ago
5 0
There are many internal factors which living organisms respond to, two of them are temperature and hormone levels. Organisms respond to internal factors in order to stay healthy and survive. The internal environment of living organisms has to be kept relatively constant, this is constancy is achieved through the process of homeostasis.
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In the presence of histones, the cis-regulatory sequences of DNA like promoter, enhancers etc. are not exposed. The function of the histone acetyltransferases (HATS) is to cause chromosome decondensation i.e. removal of histones from the DNA so that transcription of the DNA could occur. Histone acetyltransferases (HATS) cause acetylation of lysine amino acid of the histone proteins. Acetyl group is negatively charged so the acetylation of histone proteins leads to the removal of their positive charge which ultimately leads to the decrease in the interaction between N terminal of histones and negatively charged phosphate group of the DNA molecule. As soon as histones are removed from the DNA where cis-regulatory sequences are located, the DNA becomes accessible for transcription.

But here a drug has been added which blocks the activity of histone acetyltransferases (HATS) in cancer cells. So it is quite evident that in these cells, histones will not get removed from the cis-regulatory sequences of DNA so the DNA will be more closer or tightly packed as a result of which  less transcription will occur.

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