1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Vlad [161]
3 years ago
5

The interaction between DNA and histone proteins (forming nucleosomes) plays a key role in the regulation of gene expression in

eukaryotes and is a potential target mechanism in drug discovery. You are testing a drug which blocks the activity of histone acetyltransferases (HATS) in cancer cells. In general, what do you expect to happen with regards to chromatin structure and gene expression in cells treated with the drug? Please select the most correct answer.
A. The chromatin near cis-regulatory sequences will be more closed and there will be less transcription.
B. The chromatin near cis-regulatory sequences will be more open and there will be more transcription.
C. The chromatin near cis-regulatory sequences will be more open and there will be less transcription.
D.The chromatin near cis-regulatory sequences will be more closed and there will be more transcription.
E. There should be no effect on chromatin structure or gene transcription. HATs only function in the packaging of DNA prior to mitosis.
Biology
1 answer:
ladessa [460]3 years ago
7 0

Answer:

A. The chromatin near cis-regulatory sequences will be more closed and there will be less transcription.

Explanation:

In the presence of histones, the cis-regulatory sequences of DNA like promoter, enhancers etc. are not exposed. The function of the histone acetyltransferases (HATS) is to cause chromosome decondensation i.e. removal of histones from the DNA so that transcription of the DNA could occur. Histone acetyltransferases (HATS) cause acetylation of lysine amino acid of the histone proteins. Acetyl group is negatively charged so the acetylation of histone proteins leads to the removal of their positive charge which ultimately leads to the decrease in the interaction between N terminal of histones and negatively charged phosphate group of the DNA molecule. As soon as histones are removed from the DNA where cis-regulatory sequences are located, the DNA becomes accessible for transcription.

But here a drug has been added which blocks the activity of histone acetyltransferases (HATS) in cancer cells. So it is quite evident that in these cells, histones will not get removed from the cis-regulatory sequences of DNA so the DNA will be more closer or tightly packed as a result of which  less transcription will occur.

You might be interested in
Plants use different structures and processes to create offspring. Sphagnum spp. is a type of moss typically found in peat bogs.
tatiyna
<span>Which structure is part of Sphagnum spp. reproduction, but not part of fern reproduction? Answer sporophyte </span>
3 0
3 years ago
A. The sun heats the air at the equator, followed by hot air rising and moisture condensing
ira [324]

Answer:

B. Air moves towards the poles as it cools

Explanation:

The image represent convection cell or Hadley cell is a natural phenomenon in the atmosphere that occur due to difference in the density within a body of liquid or gas. These differences in density causes rise and fall in currents.

The process in step A refers to when hot air moves up and in the step B, the hot air encounters a cold surface, it direct exchange the heat with cold surface and the air cools down and move towards the poles.

Hence, the correct answer is "B. Air moves towards the poles as it cools".

8 0
3 years ago
The arrangement of the fibers and minerals in an osteon function to resist ________. Illustration of an osteon that shows how co
USPshnik [31]

Answer;

-Torsion

The arrangement of the fibers and minerals in an osteon function to resist Torsion.

Explanation;

-Compact bone tissue consists of units called osteons or Haversian systems. Osteons are cylindrical structures that contain a mineral matrix and living osteocytes connected by canaliculi, which transport blood.

Each osteon consists of concentric layers, or lamellae, of compact bone tissue that surrounds a central canal, the Haversian canal. Osteons are connected to each other and the periosteum by oblique channels called Volkmann's canals.

8 0
3 years ago
How might regular cardiorespiratory exercise affect hypertension?
weqwewe [10]
Hypertension may be reduced immediately following and for almost 24 hours after cardio respiratory exercise. The correct option among all the options that are given in the question is option "b". Regular cardio respiratory exercise is very good for people suffering from hypertension. So doing such exercises will benefit people.
5 0
3 years ago
The sense of hearing depends on which specialized cells?
slega [8]
Auditory <span>nerve cells correct

</span>
7 0
3 years ago
Read 2 more answers
Other questions:
  • Which question could be answered using DNA as a molecular clock? How old is a dinosaur bone? How long ago was a dinosaur track l
    5·2 answers
  • describe at least one reason for limiting each of the following in a well-balanced diet- saturated fat, cholesterol, and sodium
    12·1 answer
  • Which energy source would provide the cheapest electricity for a factory
    5·2 answers
  • if you were given a slide containing living cells of an unknown organism .how would you identify the cells as either plant or an
    15·2 answers
  • The tendency of people to perform simple or well-learned tasks better when others are present is the original meaning of
    7·1 answer
  • In an experiment, you create two groups of liposomes in a solution containing 0.1 M NaCl—one made from red blood cell membranes
    14·1 answer
  • The diagram illustrates the activity of vesicles during a cellular process. Which statement best explains the function of the ve
    12·2 answers
  • Can sum 1 help me plz 4. Explain: Based on the Gizmo, explain how the following transitions might take place,
    13·1 answer
  • Provide more than double the energy provided by carbohydrates or proteins in human body.
    8·2 answers
  •  What can you do to verify its purity? 
    8·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!