Groundwater is recharged naturally by rain and snow melt , hope this helps :)
This would directly affect the epidermis because blisters will develop within the surface of the skin. Having blisters on the epidermis will decrease the function of the skin to be an effective barrier to disease. This is because blisters are open wounds that are prone to infection. As infection passes through these openings, it will affect the dermis and the other layers of the skin. Bullae is actually an auto-immune skin disease.
The primary function of estrogens in women is development of female sexual characteristics during puberty. (Breasts, regulation of the menstrual cycle etc.)
In males estrogen helps in maturation of the sperm and maintenance of a healthy libido.