B. and E. marked the downfall of the Inca empire, for obvious reasons. Disease and civil war would obviously kill the empire, and taking an important leader would also mark great chaos within the empire. A. and C. are not to be ignored however, considering that maintaining peaceful relationships with the Spaniards only brought death and chaos to the Aztecs, all from the Spaniards.
I think the answer is B :))
With a form of democratic government
