Answer:
The order must be K2→K1, since the permanently active K1 allele (K1a) is able to propagate the signal onward even when its upstream activator K2 is inactive (K2i). The reverse order would have resulted in a failure to signal (K1a→K2i), since the permanently active K1a kinase would be attempting to activate a dead K2i kinase.
Explanation:
- You characterize a double mutant cell that contains K2 with type I mutation and K1 with type II
mutation.
- You observe that the response is seen even when no extracellular signal is provided.
- In the normal pathway, i f K1 activat es K2, we expect t his combinat ion of two m utants to show no response with or without ext racell ular signal. This is because no matt er how active K1 i s, it would be unable to act ivate a mutant K2 that i s an activit y defi cient. If we reverse the order, K2 activating K1, the above observati on is valid. Therefore, in the normal signaling pathway, K2 activates K1.
Chromosome duplications and deletions frequently result in abnormal phenotypes or inviable gametes. Gene dosage is modified is a major contributor to this phenomenon.
In the field of genetics, we can define gene dosage as the quantitative measure or copies of a particular gene that is present in an organism. Abnormalities in the gene dosage at a particular location can cause severe damage to the resulting phenotype.
Gene dosage can lead to chromosome duplications if the copy number or gene product is more and it can cause deletions if the copy number or gene product is less. Such complications will result in abnormal phenotypes or inviable gametes. For example, in Down's syndrome, the person has a modification of the 21st chromosome as there is one extra 21st chromosome present. This leads to a variety of diseases and defects in the person.
Although a part of your question is missing, you might be referring to this question:
Chromosome duplications and deletions frequently result in abnormal phenotypes or inviable gametes. Which factor is a major contributor to this phenomenon?
a. Recessive diseases are unmasked by additional copies.
b. The genes are found in a novel arrangement.
c. Gene dosage is modified.
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Answer:
The major structural difference between chromatin and chromosomes is that the latter are more organized and condensed.
Explanation:
Chromatin is genetic material packaged into a complex by special proteins (histones). That complex is in the form of uncoiled structures, so chromatin fibers are long and thin. Chromatin structure is permissive to DNA replication, transcription and recombination events.
On the other hand, chromosomes are highly condensed structures of genetic material that are formed just before the cell division.
This could be the superior and inferior articulate facets
Answer: A. GTATTCGTGAATCCG
B: GGTCTCATCGGTCCA
Explanation:
G goes with C and A goes with T
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