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The pyloric sphincter is compose of smooth muscle and is located between the pylorus in the stomach and duodenum of the small intestine. In digestion, it serves as a valve controlling the flow of food thus it prevents the contents of small intestine backing up into the stomach.
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Of course topography affects architecture. The ground provides the basic support for the building. If you are building on a highly sloped site, an architect must consider the slope of the site in determining the finish floor elevation, and if multiple entry levels will be needed to get in and out of the building.
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