A negative feedback loop controls the thyroid hormones.
In addition to the thyroid, the hypothalamus and pituitary are also part of the negative feedback loop. The thyroid is regulated in this manner: TRH, or thyrotropin-releasing hormone, is secreted by the hypothalamus. Thyroid-stimulating hormone, or TSH, is produced by the pituitary gland in response to TRH. The thyroid gland is then stimulated by TSH to release its hormones.
When thyroid hormone levels are high enough, the pituitary and hypothalamus are prevented from secreting TSH and TRH, respectively. The thyroid gland ceases producing hormones when TSH production is inhibited. Soon, the thyroid hormone level begins to drop too low.
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