<em>The oxidative decarboxylation of Pyruvate to form Acetyl-CoA</em> is the connection among <em>Glycolysis and the Citric acid cycle</em>
It is an irreversible oxidation process in which the <em>carboxyl group</em> is expelled from pyruvate as an atom of CO2 and the <em>two residual carbons become the acetyl group of Acetyl-CoA </em>
Pyruvate can be changed over into sugars by means of <em>gluconeogenesis, </em>to unsaturated fats or energy through <em>acetyl-CoA, to the amino acid alanine, and to ethanol</em>