Answer:
by designing a drug with steric effects on BCR-ABL1
Explanation:
Chronic myeloid leukemia (CML) is a type of cancer that affects the bone marrow and blood cells. CML is characterized by the formation of the Philadelphia chromosome, a product of a reciprocal translocation between chromosomes 9 and 22. As a consequence of this translocation, an oncoprotein tyrosine kinase called BCR-ABL1 is formed. This protein (BCR-ABL1) is responsible for 95% of all CMLs. In this case, it is possible to inhibit BCR-ABL1 (and thus inhibit CML cell proliferation) by using a kinase inhibitor. Kinase inhibitors are drugs that inhibit kinase function by preferentially binding to the inactive conformation of the target enzyme. These proteins are used to treat cancer by blocking a functional site on the kinase, thereby inhibiting its function. Moreover, it is known that steric effects alter the mode and rate by which a drug interacts with a given target. In this case, a small molecule with steric effects on BCR-ABL1, i.e., capable of altering the shape (conformation) and reactivity of BCR-ABL1, might also be used to selectively inhibit BCR-ABL1.
Answer:
a. Species A survived because of its widespread range including some areas that were not as affected by mass extinction.
Explanation:
The species distribution might confer extinction resistance during massive extinction events. One of the most important reasons for a species -or any other taxonomic group- to survive massive extinction is its wide distribution area.
The broad geographical range of a group -as Species A in the example- enhances the survival chances during mass extinctions. When the event occurs, it severely affects most individuals of a certain area. If the species is restricted to that area, then the species will probably disappear, no matter the number of individuals living there.
But if the species is widely distributed, there are more survival chances. The extinction event will only affect a few regions, but not all of them, meaning that some of the individuals of the species will be able to survive.
Probably as only a few individuals of species A got to survive, they must have suffered the effects of genetic drift after the disaster, causing a reduction in genetic variability.
This is physics, electricity.
I'll break it down for you, very easy:
you have to use the formula V=IR
where V= voltage in volts (V)
I= current in Amperes (A)
R= resistance in ohms (Ω)
so what you require is I, current there you have to rearrange the formula to subject current;
I=V/R
=9/5= 1.8Ω (ans)
Answer:
CO2
Explanation:
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Answer:
The circulatory system of a human compared to that of a frog is different due to the number of chambers. A frog’s heart has three chambers (two atria, and a single ventricle), whereas a human’s has four (two atria, and two ventricles). The atrium of a frog receives deoxygenated blood from the blood vessels that drain the various organs of the body. The left atrium receives oxygenated blood from the lungs and skin.
