Increase of earth's average temperature
Small fragments of orbiting bodies that have landed on Earth are known as meteorites. If the fragments are still orbiting earth are known as meteoroids. They are not called meteorites until they enter Earth's atmosphere. Once a meteor enters Earth's atmosphere it will begin to burn up. It may burn up completely or lose most of its size by the time is lands on Earth's surface.
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
I honestly don’t know, I just need to answer this so I can ask a question ⚪️⚪️⚪️⚪️⚪️⚪️⚪️⚪️⚪️ ⚪️⚪️⚪️⚪️⚪️⚪️⚪️⚪️⚪️ ⚪️⚪️⚪️⚪️⚪️⚪️⚪️⚪️⚪️
Answer:
d
Explanation:
others can offered and get it
