Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
#SPJ4
Alleles are two different forms of a single gene.
Answer:
skeleton muscle .......................................
It cannot take in carbon dioxide for photosynthesis
Answer:
Within the geological structure of Cayuga Lake Basin there is a diversity of limestone sources, which would make it possible for the lake to be a good location for the construction of a cement-making plant.
Explanation:
Cayuga Lake, part of the so-called Finger Lakes, located in New York, has an extension of about 40 miles. This lake is of great economic and ecological importance, because it allows fishing and recreation activities, besides being a place of passage for migratory birds.
The Skaneateles, Onandaga, Marcellus, Manilius, Moscow and Tully formations are an important source of limestone of variable quality, from which lime can be obtained for the manufacture of cement.
Although the presence of limestone would be ideal for building a cement-making plant, a project of this size should consider the environmental impact it could have.
Learn more:
brainly.com/question/13764464
