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AnnyKZ [126]
3 years ago
7

You are given a new drug to test for which there is some suspicion of hematotoxicity. Describe the testing program you would use

to determine whether the chemical is, in fact, hematotoxic. Provide a rationale for the overall testing scheme and the specific recommended tests
Medicine
1 answer:
Hoochie [10]3 years ago
5 0

The tests to be done are TC, DC, ESR, Haemoglobin content, bilirubin, and Liver function tests, and Ultrasonography of whole abdomen.

<h3><u>Explanation:</u></h3>

Haematotoxicity is defined as the property by which damage is made to blood by means of any chemical or physical means. Haematotoxic drugs actually do damage the red blood cells membrane which leads to breaking of red blood cells inside the blood vessels and leading to leakage of haemoglobin inside blood vessels. This increases the bilirubin levels in blood, causes hepatosplenomegaly, decreases red blood cell count and decreases haemoglobin content too.

So in TC and DC findings are reduced, and ESR is decreased too. In Ultrasonography, we can see the enlarged liver and spleen. The haemoglobin content is decreased and bilirubin levels is increased. In liver function tests, we will see deviated value of SGOT, SGPT, alkaline phosphatase which remarks the presence of Haematotoxic substances in blood. In extreme cases, bone marrow biopsy is done to eliminate chances of leukemia.

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Which physiological response is due to a "positive feedback loop"?
Sauron [17]

Answer: Blood loss regulation

Explanation:

Positive feed back is response of body in which there is an increase in the effect of small disturbance and the effect is intensified on a system. The magnitude of the effect increases.

In case of blood loss the body releases clotting factors that helps in preventing the body from severe blood loss.

The body releases clotting factors and these clotting factors tend to release more and more clotting factors that begins the process of blood clotting in vessels.

This is an example of positive feedback which acts as a life saving cascade.

7 0
3 years ago
The ability of older adults to adequately distribute drugs that are ingested is highly dependent on serum levels of what factor?
liraira [26]

The ability of older adults to adequately distribute drugs that are ingested is highly dependent on serum levels of Albumin.

<h3>What is Albumin?      </h3>

Albumin is the most common factor protein present in the plasma, whose levels alter many physiological and chemical processes including drug medication dissolution properties.

In conclusion, the ability of older adults to adequately distribute drugs that are ingested is highly dependent on serum levels of Albumin.

Learn more about Albumin proteins here:

brainly.com/question/18521494

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5 0
1 year ago
Whether someone with a diathesis develops the disorder is determined by
stepan [7]

Answer:

The Diathesis-Stress Model explains that psychological disorders derive from the combination of a predisposition to vulnerability or diathesis, as an innate factor, together with experiences of stress as an acquired factor. Therefore, innate factors and acquired factors are needed to develop certain disorder.

Explanation:

From the perspective of the diathesis-stress model, a disorder is the result of the interaction between a genetic predisposition or vulnerability (diathesis), with external factors or personal experiences (stress). This model is used to explain the development of mental disorders with a clear genetic basis, such as schizophrenia, bipolar disorder, etc. The appearance of the disorder will depend on the combination of both factors. The more genetic predisposition you are, the more likely you are to develop these low-stress diseases. And on the contrary, a low predisposition protects us from suffering a mental disorder, even if different stressors occur in our life.

8 0
3 years ago
Describe how the body loses heat and how muscle movement affects body temperature.
Vanyuwa [196]

Answer

heat

Explanation:

an exact temperature can make our body

move and comfort

3 0
3 years ago
Why is an increased target-receptor distance required in the paralleling technique?
klio [65]

<u>To prevent image </u><u>magnification</u> increased target-receptor distance required in the paralleling technique.

Magnification- A microscope's capacity to generate a picture of an item at a scale that is bigger (or even smaller) than its real size is known as magnification.

Target- A drug target is a biological molecule, often a protein, that is inherently linked to a certain disease process and that a medication might target to have the intended therapeutic effect.

Paralleling technique- The parallel method is the alignment of the central axis of the X-ray source so that it is perpendicular to both the plane of the film and the object being investigated. Unfortunately, it is considerably simpler to align the X-ray central axis perpendicular to the film than to the object.

To know more about the Paralleling technique, click on the below link.

brainly.com/question/28095645

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7 0
2 years ago
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