Columbus travel had affected the Native Americans living in a few ways. You could look at it from two different perspectives. Whether that be that it A: benefited the Natives or B: hurt their culture.
Going through with the benefiting... We could say that Columbus had brought new technology and skills that the Natives had never seen or used before. This could have benefited their lives and allow them to progress and further themselves.
At the same time, people could disagree with that and say that Columbus had hurt the Natives culture and way of life when he had came over. Many people would say that he disrupted the Natives way of life and in a sense had forced said life onto them even when some of them didn't want it. He had also basically took their land. As I said above, it's all about perspective and how you view it.
