People with poorly controlled diabetes are at risk of amputation due to damage of nerves in the extremities of the body. This damage to nerves is caused by chronically high blood sugar. The condition, when it is caused by uncontrolled blood sugar is called diabetic neuropathy.<span>Diabetic neuropathy mostly affects the feet and they lose feeling, such that an affected person cannot sense pain. When they develop an ulcer or small injury to the feet, it may often go unnoticed and with time become infected. High blood sugar impairs the normal healing process and the injury or ulcer may not heal quickly thus compounding the problem. The outcome of this is that the infected part e.g. a toe, may fester and even become gangrenous putting the whole bod at risk and thus the only away to save the rest of the body is removal by amputation.</span>
Some proteins do indeed need assistance during the folding process. the general term used for the proteins that help other proteins fold is Chaperones.
<h3>What are Chaperones?</h3>
- Chaperones are proteins that help big proteins or macromolecular protein complexes fold or unfold conformationally. There are different groups of molecular chaperones, all of which have the same purpose: to help big proteins fold properly during or after synthesis as well as following partial denaturation.
- Protein translocation for proteolysis involves chaperones as well. The bulk of molecular chaperones aid in protein folding by binding to and stabilizing folding intermediates up until the polypeptide chain is entirely translated, rather than providing any steric information for protein folding.
- Based on their target proteins and location, chaperones have different unique modes of operation.
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Microscope technology gives us access to some pretty important/powerful information, however some limitations to it include: resolution limit, low magnification, & poor surface view,
<span>Inflation theory is the theory explains why our universe is structured and uniform and suggests that the universe is flat in shape. According to that theory, the universe expanded exponentially fast for a fraction of a second after the Big Bang.</span>
