Hi their! The correct answer your looking for is:
C, salinity increases.
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Atp provides energy to transfer material against its concentration gradient.
Active transport transfer materials against their concentration gradient. I.e from a region of lower concentration to a region of higher concentration
        
             
        
        
        
Answer:
This is because of reasons of-
 safety, 
cost-effectiveness and
  difficulty in  accessibility of needed  protein 
Explanation:
In order to reduce cost of production for maximal profit, bio.companies usually design their production of therapeutic proteins  in possible  cost -effective way.This is to  ensure maximal yields from production sales. Therefore maximum cost  effectiveness is achieved through GMO rather through isolation from blood products or other sources which are expensive and capital intensive to get
In addition safety concerns during production is of ultimost importance to theses companies.Therefore when   using  of protein from different sources  high safety measures are needed to be put in place to achieve best results. whereas GMO comes with little risks.
These companies experiences difficulty in collecting required amount of low abundant protein needed for the synthesis of therapeutic proteins, thus they will rather prefer the design of GMO for abundant supply.