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pickupchik [31]
3 years ago
5

Why do loss of function mutations in p53 often lead to mutations in other genes?

Biology
1 answer:
klasskru [66]3 years ago
4 0
The answer to this question would be: p53 normally functions as a tumor suppressor to stop the cell cycle after DNA damage occurs<span>
The function of p53 gene is to stop the cell with damaged DNA to multiply. When the gene works, the cell with DNA damage(mutation) will not multiply, thus there are less damaged cells found. When the p53 gene is damaged, the mutated cell with damaged DNA can multiply so it can be found more.</span>
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Answer:

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A genotype is literally the underlying makeup that will produce a result that is visible and measurable, that we know as phenotype. In this particular case, we have a farmer who wishes to establish his farm with a specific type of plant: one that is tall, thornless, and has terminal flowers because they are the best for berry-picking, and that is the business he wishes to establish.

In order to be able to obtain this type of plant, he needs to first count with a starting point, the parent plants from which he will be able to produce the line he wants to establish. But to do that he needs to first know the genetic makeup with which, when he crosses the plants, he will then obtain the phenotypical results he seeks.

The question itself tells us the types of alleles (which are, in simple terms, the holders of the genetic information), that produce the phenotypical characteristics of the plants the farmer has.  So we know that there is one type of bush that is tall, thornless and has terminal flowers, and its alleles are s, t and a. The other bush has short, thorned and axial characteristics, and therefore its alleles are: S, T and A.

When the question then gives us the information about the resulting plants when the originals are selfed, and their characteristics, we are able to tell the genetic makeup, or genotype, of the original two plants the farmer has because we can combine the alleles mentioned given the characteristics (phenotypes) and thus obtain the two parent plants.  

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