The Inca and Aztec empires were heavily impacted by European exploration and colonization. The first impact was that when Europeans reached the Americas, the Incas and Aztecs were conquered which killed thousands of them and enslaved the ones that survived.
The Indians rebelled against the Americans and were defeated in a short war which led to the trail of tears
Step 1: Hold it
Step 2: Walk calmly
Step 3: Enter restroom
Step 4: Calmly sit down with pants off
Step 5: Release
I believe it's D. They spread industrial technologies and products across wide areas.