Question

What are the problems and challenges in protein structure prediction?

Answer 1

Answer:

For example, the current sequence alignment and threading algorithms have limited recognition ability for the target protein remote homologous template, the design of conformational search force field is far from accurate, the overall topology and local structure details are difficult to be optimized at the same time, the membrane protein structure which is difficult to be determined by experiments is also the soft rib of structure prediction, and the prediction of protein complex structure (fourth level structure) is still difficult.

Explanation:

http://www.creative-biostructure.com/protein-crystallization-and-structure-determination_13.htm