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SpyIntel [72]
3 years ago
13

Describe the action mechanism of labile toxin by placing the steps in the correct order.

Biology
1 answer:
vaieri [72.5K]3 years ago
6 0
I cannot found the exercise anywhere, so I will just explain how the toxin works.

A toxin is a toxic substance made by a living organism such as a bacterium, a fungus, a plant or an animal.

Labil toxins are toxins which are by easily degraded. among these toxins, there is the toxin of Escherichia coli and the cholera toxin of <span>Vibrio cholerea.
</span>
The intracellular target of cholera toxin is adenylate cyclase, one of the most important eukaryotic cell regulatory systems. This enzyme is involved in the conversion of ATP into a cyclic AMP (cAMP), a crucial intracellular messenger in a wide variety of cellular processes.
Cholera toxin catalyzes the transfer of ADP-ribose from NAD (Nicotinamide Adenine Dinucleotide) to a specific arginine residue of the Gsa protein, resulting in the activation of adenylate cyclase and consequently the increase of the intracellular level cAMP. AMPc activates a cAMP-dependent protein kinase, which leads to phosphorylation of the protein, modification of ion transport and finally diarrhea.
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