Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
I am certain 2 of out 3 of these are part of it
Explanation:
I forgot if alveoli is part of it.
Ask about ethnic origin, preferred religion, familial structure, dietary preferences, eating habits, and health practices while doing a quick cultural evaluation.
<h3>What distinguishes patient-centered care from cultural competence?</h3>
Both patient centeredness and cultural competency place differing emphasis on quality in their enhancement of health care delivery. Cultural competence largely focuses on decreasing inequities in health care, whereas patient centeredness tries to improve quality by integrating the patient perspective.
Self-care is least likely to be linked to health inequities in the nurse's mind. Self-care is not a factor that affects how marginalized populations fare in terms of health. Because they do not have access to high-quality healthcare, people in disadvantaged groups are more likely to experience health inequalities.
Learn more about cultural competency refer
brainly.com/question/26054107
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