The answer to this question would be: necrosis
Necrosis is the death of cell caused by various injury, one of them is oxygen starvation. Cells need a constant supply of energy to sustain its life. Without oxygen, the energy produced by cells will be decreased. When the energy is depleted, the cell will not be able to use ion pumps or any organelle that need energy. This will slowly damage the cell until it dies.
I do believe it's a recessive trait. I hope that helps
After surgery of the hip, or of the bones of the leg, ankle, or foot, it is of the utmost importance for recovery to get the right amount of weight-bearing when moving around with crutches or frames