Answer:
Here's what I get
Explanation:
You may have done a Williamson synthesis of guaifenesin by reacting guaiacol with 3-chloropropane-1,2-diol.
A. Mechanism
Step 1
NaOH converts guaiacol into a phenoxide ion.
Step 2
The phenoxide acts as the nucleophile in an SN2 reaction to displace the Cl from the alkyl halide.
B. Improve the yield
You probably carried out the reaction in ethanol solution — a polar protic solvent.
You might try doing the reaction in a polar aprotic solvent— perhaps DMSO.
A polar aprotic solvent does not hydrogen bond to nucleophiles, so they become stronger.
C. Another method of ether synthesis —dehydration of alcohols
Sulfuric acid catalyzes the conversion of primary alcohols to ethers.
This is also a nucleophilic displacement reaction.
Protonation of the OH converts it into a better leaving group.
Attack by a second molecule of alcohol forms the protonated ether.
A molecule of water then removes the proton.
Answer:
1: due to difference in reactivity and melting point
2 during the reaction both combine with oxygen in this case magnesium remain solid but some potassium vaporise
<h3>
<u>moles of H2SO4</u></h3>
Avogadro's number (6.022 × 1023) is defined as the number of atoms, molecules, or "units of anything" that are in a mole of that thing. So to find the number of moles in 3.4 x 1023 molecules of H2SO4, divide by 6.022 × 1023 molecules/mole and you get 0.5646 moles but there are only 2 sig figs in the given so we need to round to 2 sig figs. There are 0.56 moles in 3.4 x 1023 molecules of H2SO4
Note the way this works is to make sure the units are going to give us moles. To check, we do division of the units just like we were dividing two fractions:
(molecules of H2SO4) = (molecules of H2SO4)/1 and so we have 3.4 x 1023/6.022 × 1023 [(molecules of H2SO4)/1]/[(molecules of H2SO4)/(moles of H2SO4)]. Now, invert the denominator and multiply:
<h3 />
1 mL = 1 cm³
D = m / V
0.7857 = m / 17.16
m = 0.7857 x 17.16
m = 13.482 g
