At the end of the French and Indian War the British government signed treaties with the Indians in the Ohio territory to restrict the American colonists from moving into there land. The American colonists ignored this British treaty, and started settling in the Ohio, Kentucky, and Tennessee areas. The British government, unlike the American government in the following century (which very seldom honored the treaties they signed with the Western tribes), tried to honor their treaties with he Indians and keep the Americans out. This brought the Americans and British into confrontation and was one of the main factors that led to the Revolution.
Sickness was a big thing brought from there as we were not used to there sicknesses and we were not used to there's it's a lot like the Aztecs and the Spanish the Spanish brought small pocks
We'll by the time of 1800s the women started getting rights the civil rights just showed them that women weren't any different to men so it just helped getting the facts straighted up