Hey!
Wat a coincidence! I just gave a speech on arthritis today! :D
If arthritus destroys cartilage in a joint, everything that is supposed to support the joint - such as ligaments, muscles and tendons - will weaken, and this will lead to pain known as RA.
Someone I knew had arthritus, and when it destroyed the cartilage in her joints, she was unable to walk anymore.
Answer:
Phosphorylation within the nuclear export signal interferes with the function of the signal.
Explanation:
In biochemistry, phosphorylation is the addition of a phosphate group (PO4) to a protein or other molecule. Phosphorylation is a major player in protein regulation mechanisms, preventing protein-catalyzed reaction product from accumulating in the body causing problems.
However, in some cases phosphorylation may cause nuclear accumulation of a protein in the nucleus of the cell. An example of this is the protein shown in the question above. In this case, phosphorylation in the nuclear export signal interferes with the signal function, resulting in protein accumulation in the nucleus.
The necleus has a positive charge because the proton's are found there
