Answer:
"Action potential is a rapid rise and subsequent fall in voltage or membrane potential across a cellular membrane with a characteristic pattern."
It is the mode through which a neuron transports electrical signals.
Explanation:
- Option - (a) is the best choice to choose from,
- <u>The refractory period :</u>
A second action potential cannot occur until the membrane has recovered or reestablished, this is the refractory period. The absolute refractory period coincides with inactivation of voltage-gated sodium channels which makes it impossible to generate another nerve impulse.
Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
False
The genotype of an organism does not constitute its observable characteristics but rather its phenotype. A genotype of an organism is the genetic makeup of an organism while the phenotype is the visible characteristics.
It is, however, significant to understand that the phenotype of an organism is as a result of the interaction between the genotype and the environment.