The correct answer is: "B: The spread of epidemic diseases".
The arrival of European settlers that started with the quest of Cristopher Columbus, brought a disruptive effect to the civilizations that lived in the territories of South, Central, and North America. Besides the economic and social effects, represented in the form of trade and religion, the arrival of colonizers also exposed the locals to new diseases which they were not ready to treat themselves against. This was one important cause of deaths during this period.
Answer: On January 8, 1815, the United States achieved its greatest battlefield victory of the War of 1812 at New Orleans. The Battle of New Orleans thwarted a British effort to gain control of a critical American port and elevated Major General Andrew Jackson to national fame.
I know that manifest destiny was the mindset of Americans that they were destined to stretch from coast to coast.
The Louisiana purchase was during that time. Napoleon didn't have the troops to keep Louisiana so he sold it to us for cheap.