Question

Etoposide is used as anti-cancer drug:_______. a) It inhibits tRNA synthestase. b) It inhibits the activity of human topoisomerase II. c) It incorporates into DNA and inhibits the function of DNA polymerase III. d) It binds to the minor groove of DNA and prevents DNA replication. e) It inhibits bacterial synthesis of folic acid.

Answer 1

(b) is Right Answer

Explanation:

     (b) It inhibits the activity of human topoisomerase II.

• The broadly utilized anticancer medication Etoposide kills  cells by expanding levels of topoisomerase II-intervened DNA breaks. While it is realized that the medication demonstrations by repressing the capacity of topoisomerase II to ligate separated DNA atoms,  
• Topoisomerase inhibitors are specialists intended to meddle with the activity of topoisomerase catalysts I and II.
• It is a chemicals that control of rejoining of the phosphodiester spine of DNA strands during the ordinary cell cycle and tridimensional DNA structure.  
• Etoposide is a significant chemotherapeutic specialist that is utilized to treat a wide range of human malignant growths.
• Etoposide slaughters cells by balancing out a covalent catalyst divided DNA complex (known as the cleavage complex) that is a transient middle of the road in the synergist pattern of topoisomerase II.