The addition of an extra nucleotide to a DNA sequence produces a mutation that is called insertion. An insertion mutation can be in various sizes, from one nucleotide base pair to a section of one chromosome inserted into another. When one or more nucleotides are inserted into the genome, the processes of translation and transcription could be disrupted, resulting in altered protein synthesis.
Glucuronidation, a conjugation reaction, is thought to protect the liver by both reducing hepatic BA toxicity and increasing their urinary elimination. The present study evaluates the contribution of each process in the overall BA detoxification by glucuronidation.
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