Can you please post option too
The correct answer for the question that is being presented above is this one: "Yes, because the observed changes in histone modifications are consistent with reduced transcription." The results shown in Figure 19.5 prove conclusively that histone modifications are causing reduced Hnf4a gene transcription because <span>the observed changes in histone modifications are consistent with reduced transcription.</span>
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Correct answer choice is:
<h2>C. The question can be tested by a systematic procedure.</h2><h3>Explanation:</h3>
A scientific question is a problem that may point to a hypothesis and support us in solving the cause for any research. A good scientific question has several aspects. It should have any true results, should be testable.
A systematic process is usually intimately connected with the decisive study. In common, the purpose of a systematic process is viewed as a mechanism of control directed at decreasing the number and austerity of errors, omissions, and failures due to both human or technological functions associated.
<span>The Mediterranean dry-summer
climates usually experiences dry temperatures during summer because of the
subtropical high overhead. Mediterranean climate is also a mesothermal climate;
it means that it normally has a long, dry, and hot summer. It is usually
associated with dry summers, and in contrast, mild, rainy winters.</span>
