Answer:
The impact was most severe in the Caribbean, where by 1600 Native American populations on most islands had plummeted by more than 99 percent. Across the Americas, populations fell by 50 percent to 95 percent by 1650. The disease component of the Columbian Exchange was decidedly one-sided.
Answer:
The Knights of Labor was the first major American labor union. It was first formed in 1869 as a secret society of garment cutters in Philadelphia.
Explanation:
To the Great Lakes is the the answer.
The answer is A for this question.