Answer: Yes, negative numbers can be written in scientific notation
Examples:
-1200 = -1.2 * 10^3
-1,897,000 = -1.897 * 10^6
We simply can ignore the negative at first, then convert to scientific notation (as you normally would with any positive number). Afterward, don't forget to put the negative back in.
You can run Design of experiments to quicky collect data and fine tune an analyze you data and information. Run the experiment multiple times to confirm the data. This will help you with trend analysis.