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Pyruvate carboxylase and phosphoenolpyruvate carboxykinase catalyze reactions of gluconeogenesis that bypass the reaction of glycolysis that is catalyzed by pyruvate kinase.
<h3>Gluconeogenesis:</h3>
The tissues of some organs, including the brain, the eye, and the kidney, use glucose as their primary or only source of metabolic fuel. Glycogen stores become exhausted during a protracted fast or intense exercise, and glucose must be created from scratch to keep blood glucose levels stable. The process through which glucose is created from non-hexose precursors such glycerol, lactate, pyruvate, and glucogenic amino acids is known as gluconeogenesis.
Glycolysis is effectively reversed during glucose synthesis. However, gluconeogenesis makes use of four distinct enzymes to skip the three highly exergonic (and essentially irreversible) phases of glycolysis. The pyruvate carboxylase, PEP carboxykinase, fructose 1,6-bisphosphatase, and glucose 6-phosphatase enzymes are specific to gluconeogenesis. Gluconeogenesis can only take place in particular tissues because these enzymes are not found in all cell types. In humans, the liver and, to a lesser extent, the renal cortex are the primary locations for gluconeogenesis.
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1. Enzyme interacts with substrate
.
2. Enzyme may undergo a conformational change to capture the substrate ("induced fit" model)
3. Enzyme-substrate complex may undergo several changes to form the product(s).
4. The product(s) are released
.
5. The enzyme returns to its original form. It is then ready to do the cycle all over again.
Answer:
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24 hours is the maximum amount of time that agitation of platelets can be stopped.
<h3>What are platelets?</h3>
Platelets are pieces of very large cells in the bone marrow called megakaryocytes. They aid in the formation of blood clots that help wounds heal and to slow or stop bleeding. It can be problematic to have platelets that are too many, too few, or aren't functioning properly.
Platelets' main job is to stop and prevent bleeding. The body sends signals to platelets that direct them to the affected location when a blood artery is damaged. Adults typically have between 150,000 and 450,000 platelets per microliter of blood, which is considered normal. Less than 150,000 platelets per microliter indicate a low platelet count. People with thrombocytopenia have low platelet levels. We can bleed heavily and bruise easily if our platelet counts are low.
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