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If phospholipid bilayer diffusion is normally negligible, there will be tissues (largely lacking in transporters that may be expressed elsewhere) which, despite the relative functional similarity of their phospholipids, are very poor at taking up drugs: the blood–brain [33], blood–testis [34], and blood–retina
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to get the heat of the planet
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all of the above
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Epigenetic alterations are modifications of the genome transmitted during cell division, which do not involve changes in the DNA sequence, are hereditary and are capable of modifying gene expression. In addition, they are temporary modifications that allow DNA to be transcribed and have the ability to move histones to open or close a chromosomal region. There are three main mechanisms of epigenetic alterations: DNA methylation, histone modifications and genomic imprinting.