Answer:
What is a metabolic pathway?
Metabolic pathways could be simply defined as ways whereby reaction occurs chemically within a cell which are carried about by enzymes called metabolites, those enzymes helps in hasten up the reaction.
Explanation:
I believe it is K or rather potassium
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
Answer:
lysogenic
Explanation:
Phages can generate the lytic cycle or the lysogenic cycle, although very few are able to carry out both. If lysis is carried out, lysogeny cannot be carried out and vice versa. In the lytic cycle, phage host cells are lysed (destroyed) after replication and encapsulation of viral particles, so that new viruses are free to carry out a new infection.
On the contrary, in the lysogenic cycle there is no immediate lysis of the cell. The phage genome can be integrated into the chromosomal DNA of the host bacterium, replicating at the same time as the bacterium does, or it can remain stable in the form of a plasmid, independently replicating bacterial replication. In any case, the phage genome will be transmitted to the entire progeny of the originally infected bacteria. The phage is thus in a state of latency until the conditions of the environment are deteriorated: decrease of nutrients, increase of mutagenic agents, etc. At this time, endogenous phage or phage are activated and give rise to the lytic cycle that ends with cell lysis.
Answer: The number of protons in one atom of an element determines the atom's identity, and the number of electrons determines its electrical charge.
Explanation:
