Question

What advantage is there to phosphoglycerate kinase having an open and closed configuration?

Answer 1

Answer:

The correct answer is "The induced-fit mechanism maximizes accessibility of active site without sacrificing hydrophobic environment".

Explanation:

Phosphoglycerate kinase is an enzyme that participates in a step of glycolysis by transferring a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP, generating the following intermediary compound and a molecule of ATP. The phosphoglycerate kinase has an open and closed configuration, which has the advantage that the induced-fit mechanism maximizes accessibility of active site without sacrificing hydrophobic environment. This help the enzyme to have a more stable configuration and regulates its use in glycolysis.