The correct answer is "The induced-fit mechanism maximizes accessibility of active site without sacrificing hydrophobic environment".
Explanation:
Phosphoglycerate kinase is an enzyme that participates in a step of glycolysis by transferring a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP, generating the following intermediary compound and a molecule of ATP. The phosphoglycerate kinase has an open and closed configuration, which has the advantage that the induced-fit mechanism maximizes accessibility of active site without sacrificing hydrophobic environment. This help the enzyme to have a more stable configuration and regulates its use in glycolysis.
Because only the chromosomes can be seen in a karyotype, and microdeletions or insertions are mutations at the molecular level, it is virtually impossible to detect such mutations at the chromosomal level.
