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valina [46]
3 years ago
13

Extrapyramidal effect of metoclopramide.

Biology
1 answer:
SIZIF [17.4K]3 years ago
5 0

Answer:

Metoclopramide is a drug widely used for its antiemetic effect (that is, used for the symptomatic treatment of nausea and vomiting). Its adverse reactions are varied, affecting even the central nervous system, causing extrapyramidal syndromes.

Explanation:

Due to the antidopaminergic action of metoclopramide. Signs and symptoms can range from spasms of the muscles of the face, neck or tongue, motor agitation and tremor, acatisia (feeling restless and in need of constant movement) and acute dystonic reactions. Extrapyramidal syndrome is transient and disappears after eliminating or decreasing the dose of metoclopramide.

Metoclopramide is a drug that can be administered intravenously. Its administration can be in bolus or by a continuous infusion. Is there any method of choice to prevent or reduce the occurrence of pyramidal syndromes?

A recent systematic review concluded that, compared with bolus administration, continuous intravenous infusion of metoclopramide reduced the occurrence of extrapyramidal side effects.

With this gesture we can perform quality care and try to avoid side effects to our patients.

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If an inhibitory synapse fires at the same time and at the same distance from the initial segment as an excitatory synapse of th
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Answer:

If an inhibitory synapse fires at the same time and at the same distance from the initial segment as an excitatory synapse of the same intensity there will be no changes in the potential in the firing zone.

Explanation:

Under normal conditions, the transmembrane potential depends on the ionic charges present in the intracellular and extracellular spaces. The extracellular space load is usually positive and in the cytoplasm is negative.

  • <u>Depolarization</u> occurs by opening ion channels that allow sodium to enter the cell, making the intracellular space more positive.
  • An opening of potassium channels releases this ion to the extracellular space, leading to <u>hyperpolarization</u>.

An excitatory synapse is one capable of depolarizing a cell and boosting the production of action potential, provided it is capable of reaching the threshold of said potential.

On the other hand, an inhibitory synapse is able to hyperpolarize the cell membrane and prevent an action potential from originating, so that they can inhibit the action of an excitatory synapse.

The interaction between two synapses, one excitatory and one inhibitory, -called synapse summation- will depend on the strength that each of them possesses. In this case, the intensity of both synapses being the same, there will be no changes in the membrane potential in the firing zone.

Learn more:

Excitatory and inhibitory postsynaptic potentials brainly.com/question/3521553

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