Explanation:
The Fall of Constantinople severely hurt trades in the European region. The Ottoman conquest affected the highly lucrative Italian trade and gradually reduced trade bases in the region. Also the fall was just the first step that eventually turned the Black Sea and the Mediterranean into Turkish lakes for trade.
The Monroe Doctrine forbids European nations to colonize in the western hemisphere.
The dispersal of new food crops from the Americas was absolutely a critical reason for the development of populace. The Columbian Exchange brought about the movement of millions of individuals.