Because the exact copy of the parent cell is produced, only one organism is needed for it to occur.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Different enzymes have specific active sites which can only catalyze one <span>substrate. Enzyme-substrate complexes are produced only when the substrate fits into the active site :)</span>
1. Radiometric, Relative
2. Radiometric Dating
3. Relative Dating
<h3><u>Answer;</u></h3>
It was developed by many scientists over many decades.
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Explanation;</u></h3>
- DNA is a type of nucleic acid that contains two long, twisted strands, known as double helix, that contain complementary genetic information.
- A gene is a segment of DNA that is passed down from parents to children and confers a trait to the offspring.
- The traits an organism displays are ultimately determined by the genes it inherited from its parents, known as genotype.
- Our understanding of DNA and inherited traits has changed over time since it has been continuously developed by many scientists over may decades.
