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ladessa [460]3 years ago

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Now, the husband who is the groom will be a carrier with a probability of 2/3 since her sister is affected.

Also, the wife will be carrying a heterozygous trait since she is normal as well.

However, using Hardy-Weinberg assumption:

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$p+q =1 \\ p = 1 - q \\p = 1 - 0.02 \\p = 0.98\\$

Thus, $p^2 = (0.98)^2$

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$2pq = 2 \times 0.98 \times 0.022$

2pq = 0.0392

Finally, the required probability that there will be an affected offspring amongst the family is:

$= \dfrac{1}{4} \times \dfrac{2}{3} \times 0.0392$

$= \dfrac{1}{153}$

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