Given :
Calculate the carboplatin dose for a 60 year old man patient weighing 200 pounds.
The patient's serum creatinine is 1.2mg/dL with a target AUC of 6.
To Find :
The carboplatin dose.
Solution :
Carboplatin dose is given by :
![C.D = AUC\times [\dfrac{(140-age)\times ( weight \ in \ pounds)}{serum \ creatinine(mg/dL)\times7.2\times 2.2}+25]](https://tex.z-dn.net/?f=C.D%20%3D%20AUC%5Ctimes%20%5B%5Cdfrac%7B%28140-age%29%5Ctimes%20%28%20weight%20%5C%20in%20%5C%20pounds%29%7D%7Bserum%20%5C%20creatinine%28mg%2FdL%29%5Ctimes7.2%5Ctimes%202.2%7D%2B25%5D)
Putting all given values in above equation, we get :
![C.D = 6\times [(\dfrac{(140-60)\times ( 200)}{1.2\times72\times 2.2})+25]\\\\C.D =655.05\ mg](https://tex.z-dn.net/?f=C.D%20%3D%206%5Ctimes%20%5B%28%5Cdfrac%7B%28140-60%29%5Ctimes%20%28%20200%29%7D%7B1.2%5Ctimes72%5Ctimes%202.2%7D%29%2B25%5D%5C%5C%5C%5CC.D%20%3D655.05%5C%20mg)
Therefore, the carboplatin dose is 655.05 mg.
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