Question

"Use your knowledge of the Wnt/Frizzled signaling system to predict how gene expression will change when Lithium is added to a cell's environment. The TCF transcription factor will bind ________ frequently with the cell's DNA, resulting in _________ transcription."

Answer 1

DNA Transcription

Explanation:

• The TCF transcription factor will bind less frequently with the cell's DNA, resulting in decreasing transcription."less, decreased

• Active canonical WNT flagging outcomes in enlistment of β-catenin to DNA by TCF/LEF relatives, prompting transcriptional actuation of TCF target qualities.
• The extra translation factors have been recommended to enroll β-catenin and tie it to DNA.
• The genome-wide example of β-catenin DNA official in murine intestinal epithelium, WNT -responsive colorectal malignant growth (CRC) cells and HEK293 early stage kidney cells.
• The  two classes of β-catenin restricting locales.
• The top notch speaks to most of the DNA-bound β-catenin and co-limits with TCF4, the noticeable TCF/LEF relative in these cells.