It would be first the Neolithic revolution that has happened during the prehistoric times. Next would be the Crusades when christian army tried to retake the Holy Land from the infidels and Muslims that they were fighting against. Lastly would be the Renaissance that means rebirth. Renaissance open the world into more possibilities and open the minds of the people.
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They began trade with other people to create money and get new crops
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Antonio de Montesinos or Antonio Montesino (c. 1475 - June 27, 1540) was a Spanish Dominican friar who was a missionary on the island of Hispaniola (now the Dominican Republic and Haiti). With the backing of Friar Pedro de Córdoba and his Dominican community at Santo Domingo, Montesinos was the first European to publicly denounce the enslavement and harsh treatment of the indigenous peoples of the island. His censure initiated an enduring struggle to reform the Spanish conduct towards all indigenous people in the New World. Montesinos' outspoken criticism influenced Bartolomé de las Casas to head the humane treatment of Indians movement.
One current theory is that trade with Mesopotamia (which was very important to the Indus Valley civilization) slowed or stopped, due to Mesopotamia's own troubles at the time.
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In Congress, New Jersey Senator Theodore Frelinghuysen and Tennessee Congressman Davy Crockett spoke out against the legislation. The Removal Act passed only after bitter debate in Congress.
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