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Valentin [98]
3 years ago
6

There is a mutation in the rate limiting enzyme which prevents it from binding its substrate. How will this mutation affect the

cholesterol biosynthetic pathway, when cholesterol levels are high in the organism?
Biology
1 answer:
igor_vitrenko [27]3 years ago
6 0

Answer:

In the cholesterol biosynthetic pathway, the rate-limiting step is the reduction of HMG-CoA, which takes place in the existence of the HMG-CoA reductase enzyme. In case, when mutation takes place within the mentioned enzyme, it loses the tendency to combine with the substrate HMG-CoA, and as a consequence, the pathway fails to move forward and synthesis of cholesterol stops.  

When the levels of cholesterol are high within the organism than the mutation of the enzyme HMG-CoA reductase results in less synthesis of cholesterol within the body of the organism and will eventually assist in balancing the level of cholesterol present within the body.  

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which example of a missense mutation in a protein-encoding gene would most likely be a neutral mutation?
KATRIN_1 [288]

An example of a missense mutation in a protein-encoding gene would most likely be a neutral mutation is option B: replacement of a polar amino acid with another polar amino acid at the protein's surface.

A frequent and well-known example of a missense mutation is the blood condition sickle-cell anemia. Missense mutations exist in the DNA at a single location in sickle-cell anemia patients. A different amino acid is required in this missense mutation, which also alters the overall structure of the protein. Similarly, replacement of a polar amino acid by another polar Ami no acid at the protein's surface is a missense mutation causing change in a single site.

A neutral mutation is one whose fixation is unrelated to natural selection. Therefore, the independence of a mutation's fixation from natural selection can be used to define the selective neutrality of a mutation.

To know more about mutations, refer to the following link:

brainly.com/question/20407521

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Complete question is:

Which example of a missense mutation in a protein-encoding gene would most likely be a neutral mutation?

a) Replacement of a polar amino acid with a nonpolar amino acid at the protein's outer surface

b) Replacement of a polar amino acid with another polar amino acid at the protein's surface

c) Replacement of a polar amino acid with another polar amino acid in the protein's interior

d) Replacement of a polar amino acid with a nonpolar amino acid in the protein's interior

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I hope this helps

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