Decisions, studied I think
i believe the answer is "A fundamental role". hope this helps.
<span>temp-hgher temp results in more unloading
bohr effect-A more active tissue generates more CO2, which lowers its pH and that induces more O2 unloading
bisphosphoglycerate (BPG)-A metabolite in RBCs that binds to oxyhemoglobin and promotes O2 unloading</span>